
Rishi J. 2025 | BASIS Independent Fremont
- Project Title: Hypothesizing the Interaction Between Specific Nanoparticles and DNA Damage Response Pathways through a Meta-analysis, Monte Carlo Simulation,
- BASIS Independent Advisor: Dr. Dixit
This project focuses on the interaction between specific iron-based nanoparticles and DNA damage response (DDR) pathways, particularly in the context of double-strand breaks (DSBs). The aim is to conduct a comprehensive meta-analysis of existing literature to formulate a testable hypothesis regarding the capabilities of nanoparticles, such as Fe PNP, Ferritin-Based NP, and Fe-PLGA NP, in influencing DDR mechanisms. By reviewing relevant studies, I will explore how these nanoparticles can potentially enhance the phosphorylation of H2AX into γ-H2AX, serving as a trackable marker of DNA damage and a signal for recruiting DNA repair machinery. This research will provide crucial insights into the role of nanoparticles in cancer treatment, particularly their ability to deliver substances that stimulate DDR pathways, thereby mobilizing the cell’s repair machinery without actual DNA damage occurring. The final product will be a research paper that unites findings from the meta-analysis, contributing to the understanding of how nanoparticles can be utilized to improve cellular responses to DNA damage and enhance the efficacy of cancer therapies.