Countless species of Anopheles mosquitoes transmit malaria, and in different capacities. What variation in their genetics allows mosquito species to have different immune responses to Plasmodium parasites in different regions? There has been a resurgence of reported cases in recent years, with even the United States having recorded homegrown malaria cases for the first time in 20 years. The widespread use of antimalarial drugs, such as chloroquine and artemisinin-based therapies, has led to the selection of resistant strains, rendering some treatments less effective over time. This project’s goal is to use research based on the genetic variation in Anopheles and their immune responses, relative to geography, to develop a proposal of a potential combination of vector control strategies for malaria regulation.