Week 10 – Conclusion

Welcome Back! 

To provide a brief summary, the methodologies and results sections of my research paper were published last week. Moving forward, this week’s post will encompass the final two sections of the research paper. 

Here it is: 

Discussion: 

While researchers have identified a treatment involving memantine that displays some degree of efficacy in preventing excitotoxicity, there is no assurance that this intervention can completely prevent the occurrence of this condition. The purpose of this paper is to bring attention to the diverse range of mechanisms through which excitotoxicity may arise and to highlight the need for researchers to explore and develop alternative therapeutic options and pharmacotherapies that surpass the effectiveness of current treatments. 

Bibliography: 

1. Blanchet, P.J., Grondin, R., Bédard, P.J., Shiosaki, K., Britton, D.R., 1996. Dopamine D1 receptor desensitization profile in MPTP-lesioned primates. Eur J Pharmacol 309, 13–20. https://doi.org/10.1016/0014-2999(96)00309-3 
2. Hayes, M. T. (2019). Parkinson’s disease and parkinsonism. The American Journal of Medicine, 132(7), 802–807. https://doi.org/10.1016/j.amjmed.2019.03.001 
3. Kutzing, M. K., Luo, V., & Firestein, B. L. (2012, May). Protection from glutamate-induced excitotoxicity by memantine. Annals of biomedical engineering. https://doi.org/10.1007/s10439-011-0494-z 
4. Najib, J., 2001. Entacapone: a catechol-O-methyltransferase inhibitor for the adjunctive treatment of Parkinson’s disease. Clin Ther 23, 802–832; discussion 771. https://doi.org/10.1016/s0149-2918(01)80071-0 
5. Olanow, C.W. (2006). Rationale for considering that propargylamines might be neuroprotective in Parkinson’s disease. Neurology 66, S69-79. https://doi.org/10.1212/wnl.66.10_suppl_4.s69 
6. Yassin, M.S., Cheng, H., Ekblom, J., Oreland, L., 1998. Inhibitors of catecholamine metabolizing enzymes cause changes in S-adenosylmethionine and S-adenosylhomocysteine in the rat brain. Neurochem Int 32, 53–59. https://doi.org/10.1016/s0197-0186(97)00047-8 

End: Thanks for reading each one of my blogs for this senior project! It was fun! See You!